Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Crystal structures of a ZIP zinc transporter reveal a binuclear metal center in the transport pathway.

Science advances - 1 Aug 2017

Zhang Tuo, Liu Jian, Fellner Matthias, Zhang Chi, Sui Dexin, Hu Jian

Abstract excerpt

Zrt/Irt-like proteins (ZIPs) play fundamental roles in metal metabolism/homeostasis and are broadly involved in numerous physiological and pathological processes. The lack of high-resolution structure of the ZIPs hinders understanding of the metal transport mechanism. We report two crystal structures of a prokaryotic ZIP in lipidic cubic phase with bound metal substrates (Cd2+ at 2.7 Å and Zn2+ at 2.4 Å). The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to Biological Transport
Share to Cation Transport Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Metals

Share to Molecular Conformation

Share to Structure-Activity Relationship

Share to Zinc Fingers

Source

Open in PubMed Open full text

Identifiers

PMID: 28875161
DOI: 10.1126/sciadv.1700344
PMCID: PMC5573306

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Crystal structures of a ZIP zinc transporter reveal a binuclear metal center in the transport pathway.PMID 28875161Read ↗

Asymmetric functions of a binuclear metal center within the transport pathway of a human zinc transporter ZIP4.Semantic proximity Read ↗

The two-domain elevator-type mechanism of zinc-transporting ZIP proteinsSemantic proximity Read ↗

Histidine pairing at the metal transport site of mammalian ZnT transporters controls Zn2+ over Cd2+ selectivity.Semantic proximity Read ↗

Function, Structure, and Transport Aspects of ZIP and ZnT Zinc Transporters in Immune CellsSemantic proximity Read ↗

Zinc Homeostasis at the Bacteria/Host Interface—From Coordination Chemistry to Nutritional ImmunitySemantic proximity Read ↗

Structural insights of ZIP4 extracellular domain critical for optimal zinc transport.Semantic proximity Read ↗

Symmetry Analysis and Ancestral Sequence Reconstruction Reveal a Symmetrical Translocation Pathway and Activity Determinants of ZIP Metal TransporterSemantic proximity Read ↗

Elemental Ingredients in the Macrophage Cocktail: Role of ZIP8 in Host Response to Mycobacterium tuberculosisSemantic proximity Read ↗

The Functions of Metallothionein and ZIP and ZnT Transporters: An Overview and Perspective.Semantic proximity Read ↗

ZIP transporters‐regulated Zn 2+ homeostasis: A novel determinant of human diseasesSemantic proximity Read ↗

Targeting the selectivity filter to drastically alter the activity and substrate spectrum of a promiscuous metal transporterSemantic proximity Read ↗

Current understanding of ZIP and ZnT zinc transporters in human health and diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.