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Article

Three-dimensional structure of the human copper transporter hCTR1.

Proceedings of the National Academy of Sciences of the United States of America - 17 Mar 2009

De Feo Christopher J, Aller Stephen G, Siluvai Gnana S, Blackburn Ninian J, Unger Vinzenz M

Abstract excerpt

Copper uptake proteins (CTRs), mediate cellular acquisition of the essential metal copper in all eukaryotes. Here, we report the structure of the human CTR1 protein solved by electron crystallography to an in plane resolution of 7 A. Reminiscent of the design of traditional ion channels, trimeric hCTR1 creates a pore that stretches across the membrane bilayer at the interface between the subunits. Assignment of...

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Identifiers

PMID: 19240214
DOI: 10.1073/pnas.0810286106
PMCID: PMC2647337

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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