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Computational Protein Design Through Grafting and Stabilization.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017

Zhu Cheng, Mowrey David D, Dokholyan Nikolay V

Abstract excerpt

Computational grafting of target residues onto existing protein scaffolds is a powerful method for the design of proteins with novel function. In the grafting method side chain mutations are introduced into a preexisting protein scaffold to recreate a target functional motif. The success of this approach relies on two primary criteria: (1) the availability of compatible structural scaffolds, and (2) the...

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PMID: 27914054
DOI: 10.1007/978-1-4939-6637-0_11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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