Article

BioMetAll: Identifying Metal-Binding Sites in Proteins from Backbone Preorganization

2020-07-19

Abstract excerpt

With a large amount of research dedicated to decoding how metallic species bind to protein, in silico methods are interesting allies for experimental procedures. To date, computational predictors mostly work by identifying the best possible sequence or structural match of the target protein with metal binding templates. These approaches are fundamentally focused on the first coordination sphere of the metal. Here,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 91e14ab7-86b7-5dbc-a725-66c186e851b7
DOI: 10.26434/chemrxiv.12668651.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

BioMetAll: Identifying Metal-Binding Sites in Proteins from Backbone PreorganizationDOI 10.26434/chemrxiv.12668651.v1Read

Promiscuous Metal Site in Hepatitis B Virus X Protein Binds an Fe-S ClusterSemantic proximity Read

mCSM-metal: A Deep Learning Resource to Predict Effect of Mutations on Metal Ion Binding.Semantic proximity Read

MetalPrognosis: a Biological Language Model-based Approach for Disease-Associated Mutations in Metal-Binding Site predictionSemantic proximity Read

OptGraft: A computational procedure for transferring a binding site onto an existing protein scaffold.Semantic proximity Read

Key Structural Motifs Balance Metal Binding and Oxidative Reactivity in a Heterobimetallic Mn/Fe Protein.Semantic proximity Read

Design of artificial metalloproteins/metalloenzymes by tuning noncovalent interactions.Semantic proximity Read

Impact of copper ligand mutations on a cupredoxin with a green copper center.Semantic proximity Read

Signatures of Electron-hole Hopping in Myoglobin Peroxidase Activity Revealed by Deep Mutational LearningSemantic proximity Read

Nickel import and export in the human pathogenHelicobacter pylori, perspectives from molecular modellingSemantic proximity Read

Geometric preferences of crosslinked protein-derived cofactors reveal a high propensity for near-sequence pairs.Semantic proximity Read

MetREx: a protein design approach for the exploration of sequence-reactivity relationships in metalloenzymes.Semantic proximity Read

Modeling protein-protein complexes involved in the cytochrome C oxidase copper-delivery pathway.Semantic proximity Read