Article
Rhythmicity in mice selected for extremes in stress reactivity: behavioural, endocrine and sleep changes resembling endophenotypes of major depression.
PloS one - 1 Jan 2009
Touma Chadi, Fenzl Thomas, Ruschel Jörg, Palme Rupert, Holsboer Florian, Kimura Mayumi, Landgraf Rainer
Abstract excerpt
BACKGROUND: Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, including hyper- or hypo-activity of the stress hormone system, plays a critical role in the pathophysiology of mood disorders such as major depression (MD). Further biological hallmarks of MD are disturbances in circadian rhythms and sleep architecture. Applying a translational approach, an animal model has recently been developed,...
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