Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Behavioral despair and home-cage activity in mice with chronically elevated baseline corticosterone concentrations.

Behavior genetics - 1 Mar 2009

Malisch Jessica L, Breuner Creagh W, Kolb Erik M, Wada Haruka, Hannon Robert M, Chappell Mark A, Middleton Kevin M, Garland Theodore

Abstract excerpt

Dysfunction of the hypothalamic-pituitary-adrenal axis resulting in elevated baseline glucocorticoid concentrations is a hallmark of stress-related human anxiety and affective disorders, including depression. Mice from four replicate lines bred for high voluntary wheel running (HR lines) run almo...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Behavior
Share to Behavior, Animal
Share to Corticosterone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Depression

Share to Mice, Inbred ICR

Share to Motor Activity

Share to Sex Factors

Share to Time Factors

Source

Identifiers

PMID: 19067154
DOI: 10.1007/s10519-008-9246-8

Genes

FST
TST
CORT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19067154-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Behavioral despair and home-cage activity in mice with chronically elevated baseline corticosterone concentrations.PMID 19067154Read ↗

Depressive-like immobility behavior and genotype × stress interactions in male mice of selected strains.Semantic proximity Read ↗

Within-lifetime trade-offs but evolutionary freedom for hormonal and immunological traits: evidence from mice bred for high voluntary exercise.Semantic proximity Read ↗

Rhythmicity in mice selected for extremes in stress reactivity: behavioural, endocrine and sleep changes resembling endophenotypes of major depression.Semantic proximity Read ↗

Behavioural and Physiological Signatures of Chronic Unpredictable Mild Stress Models in MiceSemantic proximity Read ↗

A robust and reliable non-invasive test for stress responsivity in miceSemantic proximity Read ↗

Learned Immobility Produces Enduring Impairment of the HPA Axis Reactivity in Mice without Replicating the Broad Spectrum of Depressive-Like Phenotype.Semantic proximity Read ↗

Sustained running in rats administered corticosterone prevents the development of depressive behaviors and enhances hippocampal neurogenesis and synaptic plasticity without increasing neurotrophic factor levels.Semantic proximity Read ↗

Chronic running-wheel exercise from adolescence leads to increased anxiety and depression-like phenotypes in adulthood in rats: Effects on stress markers and interaction with BDNF Val66Met genotype.Semantic proximity Read ↗

Voluntary wheel running improves outcomes in an early life stress-induced model of urologic chronic pelvic pain syndrome in male miceSemantic proximity Read ↗

Genetic predisposition for high stress reactivity amplifies effects of early-life adversity.Semantic proximity Read ↗

Long-term differential effects of chronic young-adult corticosterone exposure on anxiety and depression-like behaviour in BDNF heterozygous rats depend on the experimental paradigm used.Semantic proximity Read ↗

Effects of unpredictable chronic mild stress on anxiety and depression-like behavior in miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.