Article
Behavioral despair and home-cage activity in mice with chronically elevated baseline corticosterone concentrations.
Behavior genetics - 1 Mar 2009
Malisch Jessica L, Breuner Creagh W, Kolb Erik M, Wada Haruka, Hannon Robert M, Chappell Mark A, Middleton Kevin M, Garland Theodore
Abstract excerpt
Dysfunction of the hypothalamic-pituitary-adrenal axis resulting in elevated baseline glucocorticoid concentrations is a hallmark of stress-related human anxiety and affective disorders, including depression. Mice from four replicate lines bred for high voluntary wheel running (HR lines) run almost three times as much as four non-selected control (C) lines, and exhibit two fold elevated baseline circulating...
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