Article

Behavioural and Physiological Signatures of Chronic Unpredictable Mild Stress Models in Mice

2025-12-02

Abstract excerpt

The chronic unpredictable mild stress (CUMS) paradigm is one of the most widely used preclinical models to investigate the role of stress in the neurobiology of depression and to evaluate potential antidepressant therapies, owing to its strong translational relevance. However, despite its extensive use, substantial discrepancies and concerns regarding the reproducibility of CUMS outcomes persist in the literature,...

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Literature Corpus work: a3ba47e3-5777-5ff0-9960-c5edfd082bc3
DOI: 10.64898/2025.11.30.691402

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