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Article

Antidepressant treatment differentially affects the phenotype of high and low stress reactive mice.

Neuropharmacology - 1 Nov 2016

Surget Alexandre, Van Nieuwenhuijzen Petra S, Heinzmann Jan-Michael, Knapman Alana, McIlwrick Silja, Westphal Willy-Paul, Touma Chadi, Belzung Catherine

Abstract excerpt

Modelling key endophenotypes can be a powerful approach to gain insight into mechanisms underlying the aetiology and pathophysiology of neuropsychiatric disorders. Based on evidence of stress hormone system dysregulations in depression, the Stress Reactivity (SR) mouse model has been generated by a selective breeding approach for extremes in HPA axis reactivity, resulting in high (HR), intermediate (IR) and low...

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Identifiers

PMID: 27395785
DOI: 10.1016/j.neuropharm.2016.07.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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