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Article

Requirement for Foxd3 in the maintenance of neural crest progenitors.

Development (Cambridge, England) - 1 May 2008

Teng Lu, Mundell Nathan A, Frist Audrey Y, Wang Qiaohong, Labosky Patricia A

Abstract excerpt

Understanding the molecular mechanisms of stem cell maintenance is crucial for the ultimate goal of manipulating stem cells for the treatment of disease. Foxd3 is required early in mouse embryogenesis; Foxd3(-/-) embryos fail around the time of implantation, cells of the inner cell mass cannot be maintained in vitro, and blastocyst-derived stem cell lines cannot be established. Here, we report that Foxd3 is...

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Identifiers

PMID: 18367558
DOI: 10.1242/dev.012179
PMCID: PMC2562748

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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