Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lef1 plays a role in patterning the mesoderm and ectoderm in Xenopus tropicalis.

The International journal of developmental biology - 1 Jan 2009

Roël Giulietta, Gent Yoony Y J, Peterson-Maduro Josi, Verbeek Fons J, Destrée Olivier

Abstract excerpt

Tcf/Lef HMG box transcription factors are nuclear effectors of the canonical Wnt signaling pathway, which function in cell fate specification. Lef1 is required for the development of tissues and organs that depend on epithelial mesenchymal interactions. Here, we report the effects of lef1 loss of function on early development in X. tropicalis. Depletion of lef1 affects gene expression already during gastrulation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Patterning
Share to Coronary Vessels

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Ectoderm

Share to Embryo, Nonmammalian

Share to Mesoderm

Share to TCF Transcription Factors

Share to Xenopus

Source

Identifiers

PMID: 19123129
DOI: 10.1387/ijdb.072395gr

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lef1 plays a role in patterning the mesoderm and ectoderm in Xenopus tropicalis.PMID 19123129Read ↗

Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice.Semantic proximity Read ↗

Xenopus XsalF: anterior neuroectodermal specification by attenuating cellular responsiveness to Wnt signaling.Semantic proximity Read ↗

LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis.Semantic proximity Read ↗

Tcf3 inhibits spinal cord neurogenesis by regulating sox4a expression.Semantic proximity Read ↗

The PAF1 complex component Leo1 is essential for cardiac and neural crest development in zebrafish.Semantic proximity Read ↗

Tcf3: a transcriptional regulator of axis induction in the early embryo.Semantic proximity Read ↗

Lhx2 regulates the development of the forebrain hem system.Semantic proximity Read ↗

The ventral and posterior expression of the zebrafish homeobox gene eve1 is perturbed in dorsalized and mutant embryos.Semantic proximity Read ↗

Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton.Semantic proximity Read ↗

Manipulation of endogenous regulatory elements and transgenic analyses of the Tbx1 gene.Semantic proximity Read ↗

Two tcf3 genes cooperate to pattern the zebrafish brain.Semantic proximity Read ↗

The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.