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Article

Transcriptional regulation by Pax3 and TGFbeta2 signaling: a potential gene regulatory network in neural crest development.

The International journal of developmental biology - 1 Jan 2009

Nakazaki Hiromichi, Shen Yueh-Wei, Yun Beth, Reddy Anvesh, Khanna Varun, Mania-Farnell Barbara, Ichi Shunsuke, McLone David G, Tomita Tadanori, Mayanil C Shekhar K

Abstract excerpt

Pax3 regulates neural crest cell migration and is critical during neural crest development. TGFbs modify neural crest cell migration and differentiation. TGFbeta2 nullizygous embryos (TGFbeta2(-/-)Pax3(+/+)) display open neural tube and bifid spine, whereas in wild type embryos, the neural tube is closed. In previous work, we have demonstrated that Pax3 regulates TGFbeta2 by directly binding to cis-regulatory...

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PMID: 19123128
DOI: 10.1387/ijdb.082682hn

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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