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Article

Persistent expression of Pax3 in the neural crest causes cleft palate and defective osteogenesis in mice.

The Journal of clinical investigation - 1 Jun 2008

Wu Meilin, Li Jun, Engleka Kurt A, Zhou Bo, Lu Min Min, Plotkin Joshua B, Epstein Jonathan A

Abstract excerpt

Transcription factors regulate tissue patterning and cell fate determination during development; however, expression of early regulators frequently abates upon differentiation, suggesting that they may also play a role in maintaining an undifferentiated phenotype. The transcription factor paired box 3 (Pax3) is expressed by multipotent neural crest precursors and is implicated in neural crest disorders in humans...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18483623
DOI: 10.1172/JCI33715
PMCID: PMC2381747

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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