When a case is not a case: effects of phenotype misclassification on power and sample size requirements for the transmission disequilibrium test with affected child trios.

Abstract excerpt

Phenotype misclassification in genetic studies can decrease the power to detect association between a disease locus and a marker locus. To date, studies of misclassification have focused primarily on case-control designs. The purpose of this work is to quantify the effects of phenotype misclassification on the transmission disequilibrium test (TDT) applied to affected child trios, where both parents are...

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