Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Including non-informative parents in transmission-based association tests.

Journal of human genetics - 1 Jun 2017

Kulkarni Hemant, Ghosh Saurabh

Abstract excerpt

The classical transmission disequilibrium test (TDT) based on a trio design uses information only on the allele transmitted by a heterozygous parent at a marker locus as homozygous parents are non-informative about linkage. However, the phenotype of an offspring depends on the alleles transmitted by both parents, irrespective of whether the parents are homozygous or heterozygous, and hence carry useful...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computer Simulation
Share to Genetic Diseases, Inborn
Share to Genetic Linkage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterozygote

Share to Homozygote

Share to Likelihood Functions

Share to Linkage Disequilibrium

Share to Quantitative Trait Loci

Source

Identifiers

PMID: 28202950
DOI: 10.1038/jhg.2017.9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Including non-informative parents in transmission-based association tests.PMID 28202950Read ↗

Statistical equivalent of the classical TDT for quantitative traits and multivariate phenotypes.Semantic proximity Read ↗

Method for using complete and incomplete trios to identify genes related to a quantitative trait.Semantic proximity Read ↗

Distinguishing the effects of maternal and offspring genes through studies of "case-parent triads".Semantic proximity Read ↗

New joint covariance- and marginal-based tests for association and linkage for quantitative traits for random and non-random sampling.Semantic proximity Read ↗

A novel test for detecting gene-gene interactions in trio studiesSemantic proximity Read ↗

Identifying Causal Genotype-Phenotype Relationships for Population-Sampled Parent-Child Trios.Semantic proximity Read ↗

A generalized test of genotype-phenotype causality in population-sampled nuclear families.Semantic proximity Read ↗

A Novel Test for Detecting SNP-SNP Interactions in Case-Only Trio Studies.Semantic proximity Read ↗

Review of statistical methodologies for the detection of parent-of-origin effects in family trio genome-wide association data with binary disease traits.Semantic proximity Read ↗

Transmission disequilibrium test with discordant sib pairs when parents are available.Semantic proximity Read ↗

The logistic regression model for gene-environment interactions using both case-parent trios and unrelated case-controls.Semantic proximity Read ↗

Simple association analysis combining data from trios/sibships and unrelated controls.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.