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Article

Targeted disruption of leucine-rich repeat kinase 1 but not leucine-rich repeat kinase 2 in mice causes severe osteopetrosis.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Sept 2013

Xing Weirong, Liu Jeff, Cheng Shaohong, Vogel Peter, Mohan Subburaman, Brommage Robert

Abstract excerpt

To assess the roles of Lrrk1 and Lrrk2, we examined skeletal phenotypes in Lrrk1 and Lrrk2 knockout (KO) mice. Lrrk1 KO mice exhibit severe osteopetrosis caused by dysfunction of multinucleated osteoclasts, reduced bone resorption in endocortical and trabecular regions, and increased bone mineralization. Lrrk1 KO mice have lifelong accumulation of bone and respond normally to the anabolic actions of teriparatide...

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PMID: 23526378
DOI: 10.1002/jbmr.1935
PMCID: PMC9528686

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Source receipt: pubmed, retrieved 7 Sept 2026.

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