Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice.

doi:10.1016/0092-8674(91)90499-o

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Article

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice.

Cell - 22 Feb 1991

Soriano P, Montgomery C, Geske R, Bradley A

Abstract excerpt

To understand the normal, physiological role of the c-src proto-oncogene, a null mutation was introduced into the gene by homologous recombination in mouse embryonic stem cells. Two independent targeted clones were used to generate chimeras that transmitted the mutated allele to their offspring. Intercrossing of heterozygotes gave rise to live born homozygotes, but most of these mice died within the first few...

Topics

Animals
Base Sequence
Blotting, Southern
Exons
Genes, src
Genetic Carrier Screening
Genetic Vectors
Genotype
Homozygote
Mice
Molecular Sequence Data
Mutagenesis, Insertional

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligonucleotide Probes

Osteopetrosis

Plasmids

Polymerase Chain Reaction

Recombination, Genetic

Restriction Mapping

Source

Open in PubMed

Identifiers

PMID: 1997203
DOI: 10.1016/0092-8674(91)90499-o

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1997203-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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