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Article

Src kinase activity is essential for osteoclast function.

The Journal of biological chemistry - 23 Apr 2004

Miyazaki Tsuyoshi, Sanjay Archana, Neff Lynn, Tanaka Sakae, Horne William C, Baron Roland

Abstract excerpt

Deletion of the c-src gene impairs osteoclast bone resorbing activity, causing osteopetrosis. Although it has been concluded that restoring only the Src adaptor function at least partly rescues the cell attachment and skeletal phenotypes, the contribution of Src kinase activity remains controversial. Src forms a complex with Pyk2 and Cbl after adhesion-induced stimulation of alpha(V)beta(3) integrin. To...

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Identifiers

PMID: 14739300
DOI: 10.1074/jbc.M311032200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Src kinase activity is essential for osteoclast function.PMID 14739300Read ↗

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Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice.Semantic proximity Read ↗

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