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Article

Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice.

Genes & development - 1 Nov 1997

Schwartzberg P L, Xing L, Hoffmann O, Lowell C A, Garrett L, Boyce B F, Varmus H E

Abstract excerpt

The Src tyrosine kinase has been implicated in a wide variety of signal transduction pathways, yet despite the nearly ubiquitous expression of c-src, src-/- mice show only one major phenotype-osteopetrosis caused by an intrinsic defect in osteoclasts, the cells responsible for resorbing bone. To explore further the role of Src both in osteoclasts and other cell types, we have generated transgenic mice that...

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Identifiers

PMID: 9353253
DOI: 10.1101/gad.11.21.2835
PMCID: PMC316651

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Source receipt: pubmed, retrieved 7 Sept 2026.

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