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Article

Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice.

Genes & development - 1 Nov 1997

Schwartzberg P L, Xing L, Hoffmann O, Lowell C A, Garrett L, Boyce B F, Varmus H E

Abstract excerpt

The Src tyrosine kinase has been implicated in a wide variety of signal transduction pathways, yet despite the nearly ubiquitous expression of c-src, src-/- mice show only one major phenotype-osteopetrosis caused by an intrinsic defect in osteoclasts, the cells responsible for resorbing bone. To...

Topics

Acid Phosphatase
Animals
Biomarkers, Tumor
Bone and Bones
Cells, Cultured
Chickens
Cholecalciferol
DNA Primers
Genes, src
Genotype
Humans
Interleukin-1
Isoenzymes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Knockout

Mice, Transgenic

Osteoclasts

Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 9353253
DOI: 10.1101/gad.11.21.2835
PMCID: PMC316651

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9353253-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice.PMID 9353253Read ↗

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