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Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis.

Blood - 1 Mar 1996

Lowell C A, Niwa M, Soriano P, Varmus H E

Abstract excerpt

Expression of the Src-family kinases--Src, Hck, and Fgr--increases dramatically during myeloid cell development. Src-deficient mice exhibit functional abnormalities in only one myeloid cell type, the osteoclast, resulting in impaired bone remodeling and osteopetrosis, while hck-/- or fgr-/- mice have few and subtle myeloid cell deficiencies. To determine whether these limited phenotypes are due to the...

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PMID: 8634424

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Click a neighbor to travelStep 1 · 12 closest

Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis.PMID 8634424Read ↗

Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity.Semantic proximity Read ↗

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice.Semantic proximity Read ↗

Constitutive activation of the SRC family kinase Hck results in spontaneous pulmonary inflammation and an enhanced innate immune response.Semantic proximity Read ↗

Characterization of unique functionalities in c-Src domains required for osteoclast podosome belt formationSemantic proximity Read ↗

The Src family kinase, Lyn, suppresses osteoclastogenesis in vitro and in vivo.Semantic proximity Read ↗

Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice.Semantic proximity Read ↗

The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.Semantic proximity Read ↗

Hematopoietic or Osteoclast-Specific Deletion of Syk Leads to Increased Bone Mass in Experimental MiceSemantic proximity Read ↗

A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies.Semantic proximity Read ↗

The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn.Semantic proximity Read ↗

The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B.Semantic proximity Read ↗

Targeted disruption of leucine-rich repeat kinase 1 but not leucine-rich repeat kinase 2 in mice causes severe osteopetrosis.Semantic proximity Read ↗

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