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Article

Characterization of unique functionalities in c-Src domains required for osteoclast podosome belt formation

1 Jan 2021

Abstract excerpt

Deletion of c-Src, a ubiquitously expressed tyrosine kinase, results in osteoclast dysfunction and osteopetrosis, in which bones harden into "stone." In contrast, deletion of the genes encoding other members of the Src family kinase (SFK) fails to produce an osteopetrotic phenotype. This suggests that c-Src performs a unique function in the osteoclast that cannot be compensated for by other SFKs. We aimed to...

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PMID: 34019873
DOI: 10.1016/j.jbc.2021.100790

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