Article
TP53 codon 72 polymorphism is associated with age at onset of glioblastoma.
Neurology - 27 Jan 2009
El Hallani S, Ducray F, Idbaih A, Marie Y, Boisselier B, Colin C, Laigle-Donadey F, Rodéro M, Chinot O, Thillet J, Hoang-Xuan K, Delattre J-Y, Sanson M
Abstract excerpt
BACKGROUND: Functional single nucleotide polymorphisms (SNP) in codon 72 of TP53 have been shown to be a risk factor, a prognostic marker, and related factor to age at onset in various cancers. METHODS: We investigated blood samples from 254 patients with glioblastoma and 238 healthy controls. RESULTS: TP53 codon 72 status was not correlated with prognosis and did not differ between glioblastoma and control...
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