Article
Common polymorphisms in the MDM2 and TP53 genes and the relationship between TP53 mutations and patient outcomes in glioblastomas.
Brain pathology (Zurich, Switzerland) - 1 Apr 2009
Zawlik Izabela, Kita Daisuke, Vaccarella Salvatore, Mittelbronn Michel, Franceschi Silvia, Ohgaki Hiroko
Abstract excerpt
MDM2 SNP309 is associated with younger age of tumor onset in patients with Li-Fraumeni syndrome, and TP53 codon 72 polymorphism decreases its apoptotic potential. Glioblastomas frequently show genetic alterations in the TP53 pathway. In the present study, we assessed MDM2 SNP309 in 360 glioblastomas, and correlated these with patient age and survival, as well as other alterations in the TP53 pathway. Frequencies...
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