Article
Site-specific regulation of CA(V)2.2 channels by protein kinase C isozymes betaII and epsilon.
Neuroscience - 17 Mar 2009
Rajagopal S, Fang H, Oronce C I A, Jhaveri S, Taneja S, Dehlin E M, Snyder S L, Sando J J, Kamatchi G L
Abstract excerpt
Ca(v)2.2 high voltage-gated calcium channels are regulated by phorbol-12-myristae, 13-acetate (PMA) via Ser/Thr protein kinase C (PKC) phosphorylation sites in the I-II linker and C-terminus of the alpha(1) 2.2 subunit. Here we show that PMA enhancement of Ca(v)2.2 currents expressed in Xenopus oocytes can be blocked by inhibitors of PKC betaII or PKC epsilon isozymes, as shown previously for Ca(v)2.3 currents,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.