Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibitory role of Ser-425 of the alpha1 2.2 subunit in the enhancement of Cav 2.2 currents by phorbol-12-myristate, 13-acetate.

The Journal of biological chemistry - 21 Jul 2006

Fang Hongyu, Patanavanich Saharat, Rajagopal Senthilkumar, Yi Xiaobin, Gill Monica S, Sando Julianne J, Kamatchi Ganesan L

Abstract excerpt

Voltage-gated calcium channels (Ca(v)) 2.2 currents are potentiated by phorbol-12-myristate, 13-acetate (PMA), whereas Ca(v) 2.3 currents are increased by both PMA and acetyl-beta-methylcholine (MCh). MCh-selective sites were identified in the alpha(1) 2.3 subunit, whereas the identified PMA sites responded to both PMA and MCh (Kamatchi, G. L., Franke, R., Lynch, C., III, and Sando, J. J. (2004) J. Biol. Chem....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium Channels, N-Type
Share to Methacholine Chloride

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oocytes

Share to Protein Kinase C

Share to Protein Subunits

Share to Serine

Share to Tetradecanoylphorbol Acetate

Share to Xenopus laevis

Source

Identifiers

PMID: 16704976
DOI: 10.1074/jbc.M601776200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibitory role of Ser-425 of the alpha1 2.2 subunit in the enhancement of Cav 2.2 currents by phorbol-12-myristate, 13-acetate.PMID 16704976Read ↗

Site-specific regulation of CA(V)2.2 channels by protein kinase C isozymes betaII and epsilon.Semantic proximity Read ↗

Inhibition of protein kinase C (PKC) response of voltage-gated calcium (Cav)2.2 channels expressed in Xenopus oocytes by Cavβ subunits.Semantic proximity Read ↗

Requirement of the Ca2+ channel β2 subunit for sympathetic PKA phosphorylation.Semantic proximity Read ↗

Mechanism of group IVA cytosolic phospholipase A(2) activation by phosphorylation.Semantic proximity Read ↗

Activation of protein kinase C augments T-type Ca2+ channel activity without changing channel surface density.Semantic proximity Read ↗

Calmodulin kinase II is involved in voltage-dependent facilitation of the L-type Cav1.2 calcium channel: Identification of the phosphorylation sites.Semantic proximity Read ↗

Membrane targeting of L-type calcium channels. Role of palmitoylation in the subcellular localization of the beta2a subunit.Semantic proximity Read ↗

Contribution of position alpha4S336 on functional expression and up-regulation of alpha4beta2 neuronal nicotinic receptors.Semantic proximity Read ↗

PMA counteracts G protein actions on CaV2.2 channels in rat sympathetic neurons.Semantic proximity Read ↗

Stoichiometric analysis of the TM2 6' phenylalanine mutation on desensitization in alpha1beta2 and alpha1beta2gamma2 GABA A receptors.Semantic proximity Read ↗

A threonine residue in the M2 region of the beta1 subunit is needed for expression of functional alpha1beta1 GABA(A) receptors.Semantic proximity Read ↗

2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.