Beta subunit phosphorylation selectively increases fast desensitization and prolongs deactivation of alpha1beta1gamma2L and alpha1beta3gamma2L GABA(A) receptor currents.

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Article

Beta subunit phosphorylation selectively increases fast desensitization and prolongs deactivation of alpha1beta1gamma2L and alpha1beta3gamma2L GABA(A) receptor currents.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 17 Dec 2003

Hinkle David J, Macdonald Robert L

Abstract excerpt

We studied the effects of phosphorylation by protein kinase A (PKA) on GABA(A) receptors (alpha1beta1gamma2L andalpha1beta3gamma2L) transiently expressed in HEK 293T cells. Under conditions favorable for PKA activation, currents obtained using whole-cell patch clamp of lifted cells displayed increased rate and extent of the fast phases of desensitization, decreased rate of current deactivation after GABA removal,...

Topics

Cell Line
Colforsin
Culture Media, Serum-Free
Cyclic AMP
Cyclic AMP-Dependent Protein Kinases
Electric Conductivity
Humans
Kinetics
Mutation
Patch-Clamp Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphoprotein Phosphatases

Phosphorylation

Protein Subunits

Receptors, GABA-A

Serine

gamma-Aminobutyric Acid

Source

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Identifiers

PMID: 14684872
PMCID: PMC6740942

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