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Article

Activation of protein kinase C augments T-type Ca2+ channel activity without changing channel surface density.

The Journal of physiology - 1 Dec 2006

Park Jin-Yong, Kang Ho-Won, Moon Hyung-Jo, Huh Sung-Un, Jeong Seong-Woo, Soldatov Nikolai M, Lee Jung-Ha

Abstract excerpt

T-type Ca2+ channels play essential roles in numerous cellular processes. Recently, we reported that phorbol-12-myristate-13-acetate (PMA) potently enhanced the current amplitude of Cav3.2 T-type channels reconstituted in Xenopus oocytes. Here, we have compared PMA modulation of the activities of Cav3.1, Cav3.2 and Cav3.3 channels, and have investigated the underlying mechanism. PMA augmented the current...

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Identifiers

PMID: 17008378
DOI: 10.1113/jphysiol.2006.117440
PMCID: PMC1890444

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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