Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Calmodulin kinase II is involved in voltage-dependent facilitation of the L-type Cav1.2 calcium channel: Identification of the phosphorylation sites.

The Journal of biological chemistry - 1 Sept 2006

Lee Tae-Seong, Karl Rosi, Moosmang Sven, Lenhardt Peter, Klugbauer Norbert, Hofmann Franz, Kleppisch Thomas, Welling Andrea

Abstract excerpt

Calcium-dependent facilitation of L-type calcium channels has been reported to depend on the function of calmodulin kinase II. In contrast, the mechanism for voltage-dependent facilitation is not clear. In HEK 293 cells expressing Ca(v)1.2, Ca(v)beta2a, and calmodulin kinase II, the calcium current measured at +30 mV was facilitated up to 1.5-fold by a 200-ms-long prepulse to +160 mV. This voltage-dependent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium
Share to Calcium-Calmodulin-Dependent Protein Kinase Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcium-Calmodulin-Dependent Protein Kinases

Share to Calcium Channels, L-Type

Share to Myocardium

Share to Peptides

Share to Phosphorylation

Share to Protein Structure, Tertiary

Source

Identifiers

PMID: 16820363
DOI: 10.1074/jbc.M508661200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Calmodulin kinase II is involved in voltage-dependent facilitation of the L-type Cav1.2 calcium channel: Identification of the phosphorylation sites.PMID 16820363Read ↗

Modulation of CaV2.1 channels by Ca2+/calmodulin-dependent protein kinase II bound to the C-terminal domain.Semantic proximity Read ↗

Functional properties of the CaV1.2 calcium channel activated by calmodulin in the absence of alpha2delta subunits.Semantic proximity Read ↗

Interdomain interactions control Ca2+-dependent potentiation in the cation channel TRPV4.Semantic proximity Read ↗

Structure of calmodulin bound to the hydrophobic IQ domain of the cardiac Ca(v)1.2 calcium channel.Semantic proximity Read ↗

Molecular determinants of frequency dependence and Ca2+ potentiation of verapamil block in the pore region of Cav1.2.Semantic proximity Read ↗

L-Type Ca<sub>V</sub>1.2 Calcium Channels: From In Vitro Findings to In Vivo FunctionSemantic proximity Read ↗

Site-specific regulation of CA(V)2.2 channels by protein kinase C isozymes betaII and epsilon.Semantic proximity Read ↗

Regulation of the transient receptor potential channel TRPM2 by the Ca2+ sensor calmodulin.Semantic proximity Read ↗

Inhibitory role of Ser-425 of the alpha1 2.2 subunit in the enhancement of Cav 2.2 currents by phorbol-12-myristate, 13-acetate.Semantic proximity Read ↗

Determinants for calmodulin binding on voltage-dependent Ca2+ channels.Semantic proximity Read ↗

Facilitation by a hERG blocker is induced by pore opening and operates by pore reopeningSemantic proximity Read ↗

Determinants of frequency-dependent regulation of Kv1.2-containing potassium channels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.