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Article

Inhibition of protein kinase C (PKC) response of voltage-gated calcium (Cav)2.2 channels expressed in Xenopus oocytes by Cavβ subunits.

Neuroscience - 7 Nov 2014

Rajagopal S, Fields B L, Burton B K, On C, Reeder A A, Kamatchi G L

Abstract excerpt

Cav2.2 channels are a substrate for phosphorylation by protein kinase C (PKC) isozymes. The contribution of Cavβ, an auxiliary subunit of these channels, in the PKC modulation was studied. Cav2.2 channels were expressed in Xenopus oocytes in various subunit combinations with or without Cavβ subunits. Currents were recorded using a two-electrode voltage clamp with barium as the charge carrier (IBa)....

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Identifiers

PMID: 25218964
DOI: 10.1016/j.neuroscience.2014.08.049

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