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Article

Phosphorylation sites in the Hook domain of CaVβ subunits differentially modulate CaV1.2 channel function.

Journal of molecular and cellular cardiology - 1 Oct 2015

Brunet Sylvain, Emrick Michelle A, Sadilek Martin, Scheuer Todd, Catterall William A

Abstract excerpt

Regulation of L-type calcium current is critical for the development, function, and regulation of many cell types. Ca(V)1.2 channels that conduct L-type calcium currents are regulated by many protein kinases, but the sites of action of these kinases remain unknown in most cases. We combined mass spectrometry (LC-MS/MS) and whole-cell patch clamp techniques in order to identify sites of phosphorylation of Ca(V)β...

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Identifiers

PMID: 26271711
DOI: 10.1016/j.yjmcc.2015.08.006
PMCID: PMC4637217

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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