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Article

PI3K promotes voltage-dependent calcium channel trafficking to the plasma membrane.

Nature neuroscience - 1 Sept 2004

Viard Patricia, Butcher Adrian J, Halet Guillaume, Davies Anthony, Nürnberg Bernd, Heblich Fay, Dolphin Annette C

Abstract excerpt

Phosphatidylinositol 3-kinase (PI3K) has been shown to enhance native voltage-dependent calcium channel (Ca(v)) currents both in myocytes and in neurons; however, the mechanism(s) responsible for this regulation were not known. Here we show that PI3K promotes the translocation of GFP-tagged Ca(v) channels to the plasma membrane in both COS-7 cells and neurons. We show that the effect of PI3K is mediated by...

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PMID: 15311280
DOI: 10.1038/nn1300

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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