Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium flux.

Journal of neurochemistry - 1 Mar 2009

Marongiu Roberta, Spencer Brian, Crews Leslie, Adame Anthony, Patrick Christina, Trejo Margarita, Dallapiccola Bruno, Valente Enza Maria, Masliah Eliezer

Abstract excerpt

Parkinson's disease (PD) is characterized by accumulation of alpha-synuclein (alpha-syn) and degeneration of neuronal populations in cortical and subcortical regions. Mitochondrial dysfunction has been considered a potential unifying factor in the pathogenesis of the disease. Mutations in genes linked to familial forms of PD, including SNCA encoding alpha-syn and Pten-induced putative kinase 1 (PINK1), have been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alanine
Share to alpha-Synuclein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cobalt

Share to Microscopy, Electron, Transmission

Share to Microtubule-Associated Proteins

Share to Neuroblastoma

Share to Threonine

Share to Tryptophan

Source

Open in PubMed Open full text

Identifiers

PMID: 19166511
DOI: 10.1111/j.1471-4159.2009.05932.x
PMCID: PMC3902824

Genes

PINK1
SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium flux.PMID 19166511Read ↗

The Close Encounter Between Alpha-Synuclein and MitochondriaSemantic proximity Read ↗

Elevated α-synuclein levels inhibit mitophagic fluxSemantic proximity Read ↗

Clues to how alpha-synuclein damages neurons in Parkinson's disease.Semantic proximity Read ↗

Plasma membrane ion permeability induced by mutant alpha-synuclein contributes to the degeneration of neural cells.Semantic proximity Read ↗

Loss of PINK1 Causes Age-dependent Mitochondrial Trafficking Deficits in Nigrostriatal Dopaminergic Neurons Through Aberrant Activation of p38 MAPKSemantic proximity Read ↗

α-Synuclein pathology and mitochondrial dysfunction: Toxic partners in Parkinson's diseaseSemantic proximity Read ↗

Alpha-synuclein at the intracellular and the extracellular side: functional and dysfunctional implications.Semantic proximity Read ↗

Mitophagy Upregulation Occurs Early in the Neurodegenerative Process Mediated by α-Synuclein.Semantic proximity Read ↗

Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein.Semantic proximity Read ↗

Human A53T α-synuclein causes reversible deficits in mitochondrial function and dynamics in primary mouse cortical neurons.Semantic proximity Read ↗

Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.Semantic proximity Read ↗

α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.