Article

Loss of PINK1 Causes Age-dependent Mitochondrial Trafficking Deficits in Nigrostriatal Dopaminergic Neurons Through Aberrant Activation of p38 MAPK

2024-07-19

Abstract excerpt

Mutations in PTEN-induced putative kinase 1 ( PINK1 ) cause early-onset, autosomal-recessive Parkinson’s disease (PD). While previous studies showed age-related declines in dopamine release and ATP levels in Pink1 -/- mice, the mechanisms remain unclear. Using a novel TH-Mito-Dendra2 transgenic mouse model to label dopaminergic neuron mitochondria, it is found that PINK1 loss leads to age-dependent deficits in...

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Literature Corpus work: f0daa0e5-9ba4-52da-82b4-3f80c8883696
DOI: 10.1101/2024.07.17.602426

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