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Article

Plasma membrane ion permeability induced by mutant alpha-synuclein contributes to the degeneration of neural cells.

Journal of neurochemistry - 1 May 2006

Furukawa Katsutoshi, Matsuzaki-Kobayashi Michiko, Hasegawa Takafumi, Kikuchi Akio, Sugeno Naoto, Itoyama Yasuto, Wang Yue, Yao Pamela J, Bushlin Ittai, Takeda Atsushi

Abstract excerpt

Mutations in alpha-synuclein cause some cases of familial Parkinson's disease (PD), but the mechanism by which alpha-synuclein promotes degeneration of dopamine-producing neurons is unknown. We report that human neural cells expressing mutant alpha-synuclein (A30P and A53T) have higher plasma membrane ion permeability. The higher ion permeability caused by mutant alpha-synuclein would be because of relatively...

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PMID: 16606366
DOI: 10.1111/j.1471-4159.2006.03803.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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