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Article

Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.

PloS one - 27 May 2009

Sandebring Anna, Thomas Kelly Jean, Beilina Alexandra, van der Brug Marcel, Cleland Megan M, Ahmad Rili, Miller David W, Zambrano Ibardo, Cowburn Richard F, Behbahani Homira, Cedazo-Mínguez Angel, Cookson Mark R

Abstract excerpt

PTEN-induced novel kinase 1 (PINK1) mutations are associated with autosomal recessive parkinsonism. Previous studies have shown that PINK1 influences both mitochondrial function and morphology although it is not clearly established which of these are primary events and which are secondary. Here, we describe a novel mechanism linking mitochondrial dysfunction and alterations in mitochondrial morphology related to...

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Source

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Identifiers

PMID: 19492085
DOI: 10.1371/journal.pone.0005701
PMCID: PMC2683574

Genes

PINK1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.PMID 19492085Read ↗

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A subcellular analysis of genetic modulation of PINK1 on mitochondrial alterations, autophagy and cell death.Semantic proximity Read ↗

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DJ-1 regulation of mitochondrial function and autophagy through oxidative stressSemantic proximity Read ↗

Chronic treatment with the complex I inhibitor MPP+ depletes endogenous PTEN-induced kinase 1 (PINK1) via up-regulation of Bcl-2–associated athanogene 6 (BAG6)Semantic proximity Read ↗

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