Article
Human A53T α-synuclein causes reversible deficits in mitochondrial function and dynamics in primary mouse cortical neurons.
PloS one - 1 Jan 2013
Li Li, Nadanaciva Sashi, Berger Zdenek, Shen Wei, Paumier Katrina, Schwartz Joel, Mou Kewa, Loos Paula, Milici Anthony J, Dunlop John, Hirst Warren D
Abstract excerpt
Parkinson's disease (PD) is the second most common neurodegenerative disease. A key pathological feature of PD is Lewy bodies, of which the major protein component is α-synuclein (α-syn). Human genetic studies have shown that mutations (A53T, A30P, E46K) and multiplication of the α-syn gene are linked to familial PD. Mice overexpressing the human A53T mutant α-syn gene develop severe movement disorders. However,...
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