Article
A common sequence motif associated with recombination hot spots and genome instability in humans.
Nature genetics - 1 Sept 2008
Myers Simon, Freeman Colin, Auton Adam, Donnelly Peter, McVean Gil
Abstract excerpt
In humans, most meiotic crossover events are clustered into short regions of the genome known as recombination hot spots. We have previously identified DNA motifs that are enriched in hot spots, particularly the 7-mer CCTCCCT. Here we use the increased hot-spot resolution afforded by the Phase 2 HapMap and novel search methods to identify an extended family of motifs based around the degenerate 13-mer...
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