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Article

A novel method with improved power to detect recombination hotspots from polymorphism data reveals multiple hotspots in human genes.

American journal of human genetics - 1 Nov 2005

Fearnhead Paul, Smith Nick G C

Abstract excerpt

We introduce a new method for detection of recombination hotspots from population genetic data. This method is based on (a) defining an (approximate) penalized likelihood for how recombination rate varies with physical position and (b) maximizing this penalized likelihood over possible sets of recombination hotspots. Simulation results suggest that this is a more powerful method for detection of hotspots than are...

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Identifiers

PMID: 16252238
DOI: 10.1086/497579
PMCID: PMC1271387

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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