Hotspots of Human Mutation.

Abstract excerpt

Mutation of the human genome results in three classes of genomic variation: single nucleotide variants; short insertions or deletions; and large structural variants (SVs). Some mutations occur during normal processes, such as meiotic recombination or B cell development, and others result from DNA replication or aberrant repair of breaks in sequence-specific contexts. Regardless of mechanism, mutations are subject...

Topics

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• DNA Replication
• Genome, Human
• Genomic Structural Variation
• Genomics
• Mutation
• Polymorphism, Single Nucleotide