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Article

High-resolution mapping of crossovers reveals extensive variation in fine-scale recombination patterns among humans.

Science (New York, N.Y.) - 7 Mar 2008

Coop Graham, Wen Xiaoquan, Ober Carole, Pritchard Jonathan K, Przeworski Molly

Abstract excerpt

Recombination plays a crucial role in meiosis, ensuring the proper segregation of chromosomes. Recent linkage disequilibrium (LD) and sperm-typing studies suggest that recombination rates vary tremendously across the human genome, with most events occurring in narrow "hotspots." To examine variation in fine-scale recombination patterns among individuals, we used dense, genome-wide single-nucleotide polymorphism...

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PMID: 18239090
DOI: 10.1126/science.1151851

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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