Article

Sufficient levels of BECLIN1 are required for intestinal epithelial cell homeostasis and protection against unwanted intestinal inflammation

2025-05-02

Abstract excerpt

<h4>ABSTRACT</h4> The prototypical autophagy regulator BECLIN1, orchestrates both autophagic and endocytic trafficking, and its homozygous deletion in the intestinal epithelium leads to intestinal disruption bearing similarities to inflammatory bowel disease (IBD). However, complete loss of BECLIN1 is rare in human disease. To model the effects of a partial reduction in BECLIN1, we examined mice with a monoalleli...

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Literature Corpus work: 86ca15c6-916d-5c83-8074-0ca679b504e5
DOI: 10.1101/2025.04.29.651340

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