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Article

Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells.

Nature - 2 Dec 2010

Gan Boyi, Hu Jian, Jiang Shan, Liu Yingchun, Sahin Ergün, Zhuang Li, Fletcher-Sananikone Eliot, Colla Simona, Wang Y Alan, Chin Lynda, Depinho Ronald A

Abstract excerpt

The capacity to fine-tune cellular bioenergetics with the demands of stem-cell maintenance and regeneration is central to normal development and ageing, and to organismal survival during periods of acute stress. How energy metabolism and stem-cell homeostatic processes are coordinated is not well understood. Lkb1 acts as an evolutionarily conserved regulator of cellular energy metabolism in eukaryotic cells and...

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Source

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Identifiers

PMID: 21124456
DOI: 10.1038/nature09595
PMCID: PMC3058342

Genes

PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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