Article

The metabolic kinase LKB1 shapes the enteric nervous system by mitigating the oxidative stress and p53 activity

2025-06-14

Abstract excerpt

The enteric nervous system (ENS) comprises ganglia of neurons and glial cells derived from migratory multipotent neural crest cells. While the molecular mechanisms of ENS development are well-studied, the involvement of metabolic processes has received less attention. We previously showed that the tumor suppressor kinase LKB1 is essential for the trophic maintenance of postnatal ENS. Here we examined LKB1’s role i...

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Literature Corpus work: 52daf578-ba3e-52df-a412-e4ef1afe0719
DOI: 10.1101/2025.06.10.658770

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