Article
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells.
Nature - 13 Nov 2008
Cadwell Ken, Liu John Y, Brown Sarah L, Miyoshi Hiroyuki, Loh Joy, Lennerz Jochen K, Kishi Chieko, Kc Wumesh, Carrero Javier A, Hunt Steven, Stone Christian D, Brunt Elizabeth M, Xavier Ramnik J, Sleckman Barry P, Li Ellen, Mizushima Noboru, Stappenbeck Thaddeus S, Virgin Herbert W
Abstract excerpt
Susceptibility to Crohn's disease, a complex inflammatory disease involving the small intestine, is controlled by over 30 loci. One Crohn's disease risk allele is in ATG16L1, a gene homologous to the essential yeast autophagy gene ATG16 (ref. 2). It is not known how ATG16L1 or autophagy contributes to intestinal biology or Crohn's disease pathogenesis. To address these questions, we generated and characterized...
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