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Article

Role of the nuclease activity of Saccharomyces cerevisiae Mre11 in repair of DNA double-strand breaks in mitotic cells.

Genetics - 1 Apr 2004

Lewis L Kevin, Storici Francesca, Van Komen Stephen, Calero Shanna, Sung Patrick, Resnick Michael A

Abstract excerpt

The Rad50:Mre11:Xrs2 (RMX) complex functions in repair of DNA double-strand breaks (DSBs) by recombination and nonhomologous end-joining (NHEJ) and is also required for telomere stability. The Mre11 subunit exhibits nuclease activities in vitro, but the role of these activities in repair in mitotic cells has not been established. In this study we have performed a comparative study of three mutants (mre11-D16A,...

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Source

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Identifiers

PMID: 15126391
DOI: 10.1534/genetics.166.4.1701
PMCID: PMC1470833

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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