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Article

The Mre11-Rad50-Xrs2 protein complex facilitates homologous recombination-based double-strand break repair in Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Nov 1999

Bressan D A, Baxter B K, Petrini J H

Abstract excerpt

Saccharomyces cerevisiae mre11Delta mutants are profoundly deficient in double-strand break (DSB) repair, indicating that the Mre11-Rad50-Xrs2 protein complex plays a central role in the cellular response to DNA DSBs. In this study, we examined the role of the complex in homologous recombination, the primary mode of DSB repair in yeast. We measured survival in synchronous cultures following irradiation and scored...

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Identifiers

PMID: 10523656
DOI: 10.1128/MCB.19.11.7681
PMCID: PMC84807

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