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Article

Sae2 controls Mre11 endo- and exonuclease activities by different mechanisms.

Nature communications - 22 Aug 2024

Tamai Tomoki, Reginato Giordano, Ojiri Ryusei, Morita Issei, Avrutis Alexandra, Cejka Petr, Shinohara Miki, Sugimoto Katsunori

Abstract excerpt

DNA double-strand breaks (DSBs) must be repaired to ensure cell survival and genomic integrity. In yeast, the Mre11-Rad50-Xrs2 complex (MRX) collaborates with Sae2 to initiate DSB repair. Sae2 stimulates two MRX nuclease activities, endonuclease and 3'-5' exonuclease. However, how Sae2 controls the two nuclease activities remains enigmatic. Using a combined genetic and biochemical approach, we identified a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39174552
DOI: 10.1038/s41467-024-51493-5
PMCID: PMC11341764

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Sae2 controls Mre11 endo- and exonuclease activities by different mechanisms.PMID 39174552Read ↗

Functional and molecular insights into the role of Sae2 C-terminus in the activation of MRX endonuclease.Semantic proximity Read ↗

Genetic Separation of Sae2 Nuclease Activity from Mre11 Nuclease Functions in Budding Yeast.Semantic proximity Read ↗

Functional interplay between the 53BP1-ortholog Rad9 and the Mre11 complex regulates resection, end-tethering and repair of a double-strand break.Semantic proximity Read ↗

Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex.Semantic proximity Read ↗

Sae2 and Rif2 regulate MRX endonuclease activity at DNA double-strand breaks in opposite manners.Semantic proximity Read ↗

Genetic and biochemical evidences reveal novel insights into the mechanism underlying Saccharomyces cerevisiae Sae2-mediated abrogation of DNA replication stress.Semantic proximity Read ↗

Molecular insights into the activation of Mre11-Rad50 endonuclease activity by Sae2/CtIP.Semantic proximity Read ↗

Sae2 promotes DNA damage resistance by removing the Mre11-Rad50-Xrs2 complex from DNA and attenuating Rad53 signaling.Semantic proximity Read ↗

The Saccharomyces cerevisiae Sae2 protein promotes resection and bridging of double strand break ends.Semantic proximity Read ↗

The pendulum of the Ku-Ku clockSemantic proximity Read ↗

Molecular insights into the activation of Mre11-Rad50 endonuclease activity by Sae2/CtIPSemantic proximity Read ↗

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