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Article

Molecular insights into the activation of Mre11-Rad50 endonuclease activity by Sae2/CtIP.

Molecular cell - 20 Jun 2024

Nicolas Yoann, Bret Hélène, Cannavo Elda, Acharya Ananya, Cejka Petr, Borde Valérie, Guerois Raphaël

Abstract excerpt

In Saccharomyces cerevisiae (S. cerevisiae), Mre11-Rad50-Xrs2 (MRX)-Sae2 nuclease activity is required for the resection of DNA breaks with secondary structures or protein blocks, while in humans, the MRE11-RAD50-NBS1 (MRN) homolog with CtIP is needed to initiate DNA end resection of all breaks. Phosphorylated Sae2/CtIP stimulates the endonuclease activity of MRX/N. Structural insights into the activation of the...

Topics

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Acid Anhydride Hydrolases
DNA Breaks, Double-Stranded
DNA Repair Enzymes
Endodeoxyribonucleases
Endonucleases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Enzyme Activation

Exodeoxyribonucleases

MRE11 Homologue Protein

Source

Identifiers

PMID: 38870937
DOI: 10.1016/j.molcel.2024.05.019

Genes

MRE11
RAD50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Molecular insights into the activation of Mre11-Rad50 endonuclease activity by Sae2/CtIP.PMID 38870937Read ↗

Molecular insights into the activation of Mre11-Rad50 endonuclease activity by Sae2/CtIPSemantic proximity Read ↗

Functional and molecular insights into the role of Sae2 C-terminus in the activation of MRX endonuclease.Semantic proximity Read ↗

Sae2 and Rif2 regulate MRX endonuclease activity at DNA double-strand breaks in opposite manners.Semantic proximity Read ↗

Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repairSemantic proximity Read ↗

Sae2 controls Mre11 endo- and exonuclease activities by different mechanisms.Semantic proximity Read ↗

Genetic and biochemical evidences reveal novel insights into the mechanism underlying Saccharomyces cerevisiae Sae2-mediated abrogation of DNA replication stress.Semantic proximity Read ↗

Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex.Semantic proximity Read ↗

Functional interplay between the 53BP1-ortholog Rad9 and the Mre11 complex regulates resection, end-tethering and repair of a double-strand break.Semantic proximity Read ↗

Mre11–Rad50–Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin templateThis paper is one of a selection of papers published in this Special Issue, entitled 28th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.Semantic proximity Read ↗

Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling.Semantic proximity Read ↗

Sae2/CtIP prevents R-loop accumulation in eukaryotic cellsSemantic proximity Read ↗

Sae2 promotes DNA damage resistance by removing the Mre11-Rad50-Xrs2 complex from DNA and attenuating Rad53 signaling.Semantic proximity Read ↗

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