Article

Molecular insights into the activation of Mre11-Rad50 endonuclease activity by Sae2/CtIP

2023-08-05

Abstract excerpt

<h4>Summary</h4> In S. cerevisiae , the Mre11-Rad50-Xrs2 (MRX)-Sae2 nuclease activity is required for the resection of DNA breaks with secondary structures or protein blocks, while in humans, the MRE11-RAD50-NBS1 (MRN) homologue with CtIP is needed to initiate DNA end resection of all breaks. Phosphorylated Sae2/CtIP stimulates the endonuclease activity of MRX/N. Structural insights into the activation of the Mr...

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Literature Corpus work: 1c0e212b-3288-560c-a5ec-9ed6082472c7
DOI: 10.1101/2023.08.05.552090

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