Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

N-Glycan Moieties in Neonatal Fc Receptor Determine Steady-state Membrane Distribution and Directional Transport of IgG.

The Journal of biological chemistry - 27 Mar 2009

Kuo Timothy T, de Muinck Eric J, Claypool Steven M, Yoshida Masaru, Nagaishi Takashi, Aveson Victoria G, Lencer Wayne I, Blumberg Richard S

Abstract excerpt

The neonatal Fc receptor (FcRn) is a major histocompatibility complex class I-related molecule known to protect IgG and albumin from catabolism and transport IgG across polarized epithelial cells in a bidirectional manner. Previous studies have shown species-specific differences in ligand binding, IgG transport direction, and steady-state membrane distribution when expressed in polarized epithelial cells. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Albumins
Share to Cell Polarity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial Cells

Share to Histocompatibility Antigens Class I

Share to Immunoglobulin G

Share to Polysaccharides

Share to Protein Processing, Post-Translational

Share to Receptors, Fc

Source

Open in PubMed Open full text

Identifiers

PMID: 19164298
DOI: 10.1074/jbc.M805877200
PMCID: PMC2659187

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

N-Glycan Moieties in Neonatal Fc Receptor Determine Steady-state Membrane Distribution and Directional Transport of IgG.PMID 19164298Read ↗

Multiple Roles for the Major Histocompatibility Complex Class I– Related Receptor FcRnSemantic proximity Read ↗

The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinitySemantic proximity Read ↗

Regulation of Immune Responses by the Neonatal Fc Receptor and Its Therapeutic ImplicationsSemantic proximity Read ↗

Divergent activities of an engineered antibody in murine and human systems have implications for therapeutic antibodies.Semantic proximity Read ↗

FcRn, but not FcγRs, drives maternal-fetal transplacental transport of human IgG antibodiesSemantic proximity Read ↗

FcRn, but not FcγRs, drives maternal-fetal transplacental transport of human IgG antibodiesSemantic proximity Read ↗

Identification of critical IgG binding epitopes on the neonatal Fc receptor.Semantic proximity Read ↗

The immunologic functions of the neonatal Fc receptor for IgG.Semantic proximity Read ↗

Neonatal Fc receptor (FcRn): a novel target for therapeutic antibodies and antibody engineering.Semantic proximity Read ↗

Anti-carcinoembryonic Antigen Single-chain Variable Fragment Antibody Variants Bind Mouse and Human Neonatal Fc Receptor with Different Affinities That Reveal Distinct Cross-species Differences in Serum Half-lifeSemantic proximity Read ↗

Maternofetal transplacental transport of recombinant IgG antibodies lacking effector functionsSemantic proximity Read ↗

Humanized IgG1 variants with differential binding properties to the neonatal Fc receptor: relationship to pharmacokinetics in mice and primates.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.