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Article

Humanized IgG1 variants with differential binding properties to the neonatal Fc receptor: relationship to pharmacokinetics in mice and primates.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2007

Datta-Mannan Amita, Witcher Derrick R, Tang Ying, Watkins Jeffry, Jiang Weidong, Wroblewski Victor J

Abstract excerpt

It is well established that the neonatal Fc receptor (FcRn) plays a critical role in regulating IgG homeostasis in vivo. As such, modification of the interaction of IgG with FcRn has been the focus of protein-engineering strategies designed to generate therapeutic antibodies with improved pharmacokinetic properties. In the current work, we characterized differences in interaction of IgG between mouse and primate...

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Identifiers

PMID: 17050651
DOI: 10.1124/dmd.106.011734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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